Correlating Anisotropic Nanoindentation Responses with Bulk Powder Tableting on Two Habits of Famotidine Form B
نویسندگان
چکیده
Famotidine Form B P. P. Upadhyay, M. K. Mishra, U. Ramamurty, A. D. Bond University of Copenhagen, Indian Institute of Science, University of Cambridge Purpose Polymorphs are well known to have different mechanical properties. Nanoindentation enables mechanical properties to be tested on single crystals, which should provide the best opportunity to establish a correlation with single-crystal X-ray structures. Nanoindentation was performed on the major faces of two habits of famotidine form B, and correlated with the crystal structure using energy-vector models generated by the PIXEL and processPIXEL programs. Bulk powder tableting behavior was tested for the two crystal habits.
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